Reds vs Cubs Prediction & Best Bets | Pitching Duel at Wrigley Field

by | May 31, 2025 | mlb

Nick Lodolo Cincinnati Reds Starting Pitcher

The Cincinnati Reds (29-29) visit the Chicago Cubs (35-22) for the second game of their weekend series at Wrigley Field after Cincinnati took game one 6-2 behind Andrew Abbott’s stellar pitching performance. Today’s matchup features an intriguing battle between Reds lefty Nick Lodolo against Cubs opener Drew Pomeranz, who will be followed by Ben Brown. With both teams featuring quality arms and the Cubs trying a new strategic approach to solve Brown’s first-inning struggles, I’m targeting a low-scoring affair that offers several betting edges worth exploiting in what should be an NL Central classic.

Quick Picks:

  • Best Bet: Under 7.5 Runs (-110) ★★★★☆
  • Top Prop: Nick Lodolo Over 5.5 Strikeouts (-120) ★★★★☆
  • Value Play: Cincinnati Reds +1.5 (-130) ★★★☆☆

Cincinnati Reds vs Chicago Cubs Betting Odds & Latest Line Movement

Market Cincinnati Reds Chicago Cubs
Moneyline +135 -160
Run Line +1.5 (-130) -1.5 (+110)
Total Over 7.5 (-110) Under 7.5 (-110)

Opening Line: Cubs -155, Total 8

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

Since opening, I’ve noticed a slight steam move on the Cubs moneyline (from -155 to -160) despite yesterday’s loss, indicating professional confidence in their bounceback ability with Pomeranz opening. The total has seen more significant movement, dropping from 8 to 7.5, with approximately 65% of the money coming in on the under according to consensus data. This suggests sharp bettors are anticipating a lower-scoring affair than the market initially projected. The run line has also seen some subtle movement with the juice on Cincinnati’s +1.5 inching from -125 to -130, showing some resistance to the Cubs as bigger favorites.

Pitching Matchup: Nick Lodolo vs Drew Pomeranz – Who Has the Edge?

Cincinnati Reds: Nick Lodolo (4-4, 3.39 ERA)

  • Lodolo has been a model of consistency, posting a stellar 55:12 K:BB ratio across 63.2 innings
  • His 1.10 WHIP demonstrates excellent command and ability to limit baserunners
  • Has allowed 3 ER or fewer in 8 of his last 9 starts, showing excellent reliability
  • Left-handed pitching neutralizes some of the Cubs’ most dangerous right-handed bats

Chicago Cubs: Drew Pomeranz (2-0, 0.00 ERA)

  • Pomeranz has been untouchable in relief, not allowing a single earned run in 12.2 innings
  • Incredibly efficient with a 14:3 K:BB ratio and 0.55 WHIP
  • Will serve as opener for Ben Brown, who has struggled in first innings (9.90 ERA)
  • The strategic opener approach is designed to help Brown avoid early trouble against Reds’ top hitters

Advantage: Slight edge to Cincinnati. While Pomeranz has been excellent, he’ll only work 1-2 innings before giving way to the inconsistent Brown. Lodolo offers more certainty with his ability to work deeper into the game with consistent effectiveness.

Bullpen Breakdown

The Cubs bullpen holds a statistical edge with a collective 3.28 ERA compared to Cincinnati’s 3.76, but recent usage trends favor the Reds. Chicago had to use three relievers yesterday after Rea’s rough outing, while Cincinnati’s bullpen was relatively fresh thanks to Abbott’s seven strong innings. The Cubs are taking a risk by using Pomeranz as an opener, potentially limiting their late-inning options. Meanwhile, Reds closer Emilio Pagán (14 saves) has been rock-solid despite some drama in the ninth inning yesterday. If this game stays close into the late innings, the bullpen chess match could prove decisive, with Cincinnati potentially holding more high-leverage arms in reserve.

Key Betting Trends & Team Statistics That Matter

  • The Cubs are a solid 18-11 at Wrigley Field this season, though they’ve lost 2 of their last 3 home games
  • Cincinnati is exactly .500 on the road at 15-15, showing they’re a competent traveling team
  • The Cubs rank 3rd in MLB in team slugging percentage (.448), while the Reds are 18th (.401)
  • Under Craig Counsell, the Cubs are 7-3 this season when using strategic bullpen games
  • Nick Lodolo has allowed 2 or fewer earned runs in 6 of his last 8 starts
  • The season series between these teams is perfectly split at 2-2
  • Five of the last seven meetings between these teams at Wrigley have gone under the total

Elly De La Cruz’s Impact: How the Dynamic Shortstop Threatens the Cubs

Elly De La Cruz has been a catalyst for the Reds offense, hitting .300 with 4 doubles and 3 home runs over his last 10 games. His elite speed adds another dimension that Chicago must account for, especially with the Cubs allowing the 5th most stolen bases in the league. The opener strategy with Pomeranz followed by Brown creates an interesting dynamic, as De La Cruz historically performs better against right-handed pitching (.275 vs RHP, .243 vs LHP). Once Brown enters, watch for De La Cruz to become more aggressive both at the plate and on the basepaths. His ability to create offense single-handedly could be the difference-maker in what projects to be a tight, low-scoring contest.

Wrigley Field Factor: How the Venue Influences Today’s Game

Today’s forecast at Wrigley Field calls for temperatures around 68°F with moderate 8-10 mph winds blowing in from left field, creating pitcher-friendly conditions. The afternoon start time eliminates the notorious shadows that can trouble hitters during twilight games. Wrigley has played as a neutral park this season (1.02 run factor), but the wind conditions specifically favor pitchers today. The Cubs have scored 5+ runs in 11 of their last 15 home games, but they’ll be facing a tougher challenge against Lodolo’s quality arsenal. The atmospheric conditions and Lodolo’s pitching style align perfectly for a lower-scoring affair than we’d typically expect from these offenses.

Expert Prediction & Best Bets for Reds-Cubs Showdown

Primary Play: Under 7.5 Runs (-110)

This total has already moved from 8 to 7.5, but I still see value at the current number. Nick Lodolo has been consistently effective, and the Cubs’ opener strategy with Pomeranz should neutralize Cincinnati’s top of the order at least once. The wind blowing in at Wrigley creates pitcher-friendly conditions, and both bullpens have been solid overall this season. Yesterday’s game looked like it would stay under until the Cubs broke through late, but only for two runs. I’m expecting another tight, low-scoring contest where runs are at a premium. I’d play this down to 7 if it continues to move.

Strong Value Play: Nick Lodolo Over 5.5 Strikeouts (-120)

Lodolo’s swing-and-miss stuff has been impressive this season, with 55 Ks in 63.2 innings. The Cubs have been susceptible to strikeouts against left-handed pitching, ranking 11th in K-rate versus southpaws. In his last outing against a comparable lineup, Lodolo recorded 7 strikeouts, and I’m expecting similar production today. His breaking ball has been particularly effective, generating a 32% whiff rate that should play well against Chicago’s aggressive approach. Lodolo should work deep enough into this game to clear this reasonable strikeout threshold.

Worth Considering: Cincinnati Reds +1.5 (-130)

While the Cubs deserve to be favored at home, the Reds have shown they can hang with Chicago. Yesterday’s convincing win demonstrated their capability, and Lodolo gives them a reliable starter who can keep games close. The Cubs’ opener strategy adds an element of uncertainty that benefits the run line play. Cincinnati is 18-13 as an underdog this season, showing their competitiveness in these situations. With the Reds playing solid .500 baseball on the road, I like their chances to at least keep this game within a run.

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Nick Lodolo Over 5.5 Strikeouts -120 ★★★★☆
Elly De La Cruz To Record a Stolen Base +175 ★★★★☆
TJ Friedl Over 1.5 Total Bases +140 ★★★☆☆
Kyle Tucker Under 1.5 Total Bases -120 ★★★☆☆

Final Thoughts: Pitching Rules the Day at Wrigley

Today’s matchup sets up perfectly for a classic NL Central pitching duel. The Cubs’ creative opener strategy with Pomeranz is intriguing, but I believe Lodolo’s consistency gives Cincinnati the more reliable starting option. Both offenses have shown flashes of brilliance mixed with inconsistency, and the weather conditions at Wrigley Field favor the pitchers today. The value in this game lies with the under and backing Lodolo’s strikeout prowess against a Cubs lineup that can be overly aggressive at times. While I slightly lean Cincinnati on the run line, my strongest play is the under in what should be a tense, low-scoring affair between division rivals.

Score Prediction: Cincinnati Reds 3, Chicago Cubs 2

100% Free Play up to $1,000 (Crypto Only)

BONUS CODE: PREDICTEM

BetOnline

MLB Betting Guide

New to betting on baseball? We’ve got you covered! Our comprehensive how to bet on baseball article explains all the different types of wagers offered at the sportsbooks including money lines, over/unders, run lines, parlays and more! Also get tips and strategies to increase your odds of beating the bookies!