Cleveland Guardians vs Detroit Tigers MLB Pick May 23rd

by | May 23, 2025 | mlb

Andy Ibanez Detroit Tigers

The Cleveland Guardians (27-22) head to Motown for a pivotal four-game series against the AL-best Detroit Tigers (33-18) beginning Friday night at Comerica Park. Coming off an impressive 7-0 shutout win in the series opener, Cleveland looks to continue narrowing the gap in the AL Central race. With the pitching matchup featuring promising youngsters Slade Cecconi and Jackson Jobe, this second game offers intriguing betting opportunities worth examining.

Guardians vs Tigers Betting Odds

Market Cleveland Guardians Detroit Tigers
Moneyline +112 -129
Run Line +1.5 (-155) -1.5 (+135)
Total Over 8.5 (-110) Under 8.5 (-110)

Opening Line: Tigers -125, Total 8

Pitching Matchup Analysis

Cleveland Guardians: Slade Cecconi (0-1, 5.40 ERA)
– Making just his second start for Cleveland after being called up from Triple-A
– Impressed in debut with 8 strikeouts across 5 innings against Cincinnati
– Features a four-pitch mix with fastball sitting 94-96 mph
– Command has been inconsistent with 3 walks in his lone start

Detroit Tigers: Jackson Jobe (4-0, 4.12 ERA)
– Top prospect has been impressive in rookie campaign
– Perfect 4-0 record with 41 strikeouts in 39.1 innings
– Has shown excellent command with just 13 walks on the season
– Coming off strong outing against Toronto (6 IP, 2 ER, 7 K)

Advantage: Slight edge to Detroit. While Cecconi showed promise in his debut, Jobe has been consistent and has more MLB experience this season. His perfect record at home (3-0, 3.21 ERA) gives him the nod.

Key Offensive Metrics

The offensive comparison clearly favors Detroit, which has been among the league’s most productive lineups:

Stat Cleveland Detroit
Runs/Game 4.06 5.24
Batting Avg .233 .257
OPS .688 .745
Home Runs/Game 1.10 1.22

Recent Form & Trends

  • Cleveland snapped a five-game losing streak with Thursday’s 7-0 victory
  • The Guardians are just 3-7 in their last 10 games overall
  • Detroit had won 7 of 9 before dropping Thursday’s series opener
  • The Tigers are 18-8 at home this season, one of the best home records in baseball
  • Guardians are 13-11 on the road and have struggled against winning teams (11-15)

Injury Situations to Monitor

Cleveland Guardians:
– Lane Thomas (wrist) returned to the lineup Thursday after a month-long IL stint
– Will Brennan (forearm) was placed on the 10-day IL

Detroit Tigers:
– Gleyber Torres (leg) left Thursday’s game with lower right leg discomfort, status uncertain
– Matt Vierling (shoulder) is nearing return from rehab assignment
– Reese Olson (finger) and Casey Mize (hamstring) remain on the IL

Bullpen Breakdown

Cleveland’s bullpen was magnificent in the series opener, with Cade Smith striking out three straight batters with the bases loaded to preserve the shutout. The Guardians’ relief corps has been a strength all season, posting a collective 3.41 ERA.

Detroit’s bullpen has been solid as well with a 3.55 ERA, but Thursday’s game exposed some vulnerabilities in middle relief. The Tigers’ late-inning trio of Shelby Miller, Andrew Chafin, and Jason Foley remains one of the AL’s best when they have the lead.

Weather & Park Factors

Friday’s forecast calls for temperatures in the mid-60s with moderate winds blowing in from left field. Comerica Park typically plays as a pitcher-friendly venue, with its spacious outfield suppressing home runs. This could benefit Cecconi, who allowed a home run in his debut.

Expert Prediction & Best Bets

Game Analysis: Thursday’s shutout was a statement win for Cleveland, but Detroit’s home dominance and offensive firepower make them rightful favorites in this matchup. While Cecconi showed promise in his debut, asking him to replicate that performance against the AL’s best team is a tall order. Jobe has been remarkably poised for a rookie and should give the Tigers a quality start.

The Cleveland offense remains inconsistent, relying heavily on José Ramirez and Steven Kwan at the top of the order. Lane Thomas’s return helps, but the lineup still lacks the depth that Detroit possesses. Meanwhile, the Tigers’ offense should rebound after being blanked in the opener.

Primary Play: Detroit Tigers Moneyline (-129) ★★★★☆

The Tigers are simply the better team right now, especially at home where they’ve been dominant. Jobe has yet to lose a decision this season, and the Tigers are 6-1 in his starts. Cleveland’s victory yesterday likely sets up a strong bounce-back spot for Detroit. I’d play this up to -140.

Value Play: Under 8.5 Runs (-110) ★★★☆☆

With Comerica Park’s pitcher-friendly dimensions and moderate winds blowing in, runs could be at a premium. Both starters have shown the ability to miss bats, and Cleveland’s lack of offensive production (just 4.06 runs/game) makes the under appealing. The Guardians have gone under in 7 of their last 10 road games.

Player Prop Worth Targeting: José Ramirez Over 1.5 Total Bases (+105) ★★★★☆

Ramirez is in the midst of a 14-game hitting streak and is batting .311 with a .967 OPS on the road this season. He collected three hits in Thursday’s opener and has historically performed well at Comerica Park. Against a young pitcher like Jobe, I expect the All-Star third baseman to continue his hot streak.

Despite Cleveland’s impressive showing in the series opener, Detroit’s consistent home performance and offensive firepower should help them even the series. Look for a competitive game that ultimately sees the Tigers prevail behind Jobe’s quality start and a resurgent offensive effort.

100% Free Play up to $1,000 (Crypto Only)

BONUS CODE: PREDICTEM

BetOnline

MLB Betting Guide

New to betting on baseball? We’ve got you covered! Our comprehensive how to bet on baseball article explains all the different types of wagers offered at the sportsbooks including money lines, over/unders, run lines, parlays and more! Also get tips and strategies to increase your odds of beating the bookies!