Astros vs Pirates Prediction & Best Bets | Skenes Looks to Silence Struggling Astros

by | Jun 3, 2025 | mlb

Paul Skenes Starting Pitcher Pittsburgh Pirates

The Pittsburgh Pirates (22-38) return home to PNC Park to host the Houston Astros (32-27) in an intriguing interleague matchup featuring a tale of two pitchers on vastly different trajectories. This series opener presents a fascinating contrast as we see Pirates phenom Paul Skenes, the reigning NL Rookie of the Year, square off against Lance McCullers Jr., who continues his comeback from a lengthy injury absence. Despite Pittsburgh’s overall struggles, Skenes has been a lone bright spot, while the Astros look to build on their recent momentum and maintain pressure on Seattle in the AL West race.

Quick Picks:

  • Best Bet: Pittsburgh Pirates Moneyline (-145) ★★★★☆
  • Top Prop: Paul Skenes Over 7.5 Strikeouts (+105) ★★★★☆
  • Value Play: Under 7.5 Total Runs (-110) ★★★☆☆

Houston Astros vs Pittsburgh Pirates Betting Odds & Latest Line Movement

Market Houston Astros Pittsburgh Pirates
Moneyline +122 -145
Run Line +1.5 (-155) -1.5 (+135)
Total Over 7.5 (-110) Under 7.5 (-110)

Opening Line: Pirates -140, Total 7.5

Sharp Money Analysis: Where Pro Bettors Are Placing Their Wagers

The line movement on this game has been minimal, with the Pirates seeing a slight bump from -140 to -145 since opening. This minor movement suggests professional bettors are generally in agreement with the opening line’s assessment despite the significant disparity between these teams’ overall records. What’s interesting is the lack of movement on the total despite Skenes’ dominance and Pittsburgh’s anemic offense. The sharps seem to be recognizing that while the Pirates struggle to score, McCullers remains vulnerable as he works his way back to form, creating enough uncertainty to keep the total steady at 7.5.

Pitching Matchup: Lance McCullers vs Paul Skenes – Who Has the Edge?

Houston Astros: Lance McCullers (0-1, 5.89 ERA)

  • Still finding his form after a lengthy injury layoff with just 18.1 innings pitched this season
  • Impressive strikeout rate (12.8 K/9) but concerning command issues (5.4 BB/9)
  • Coming off his best outing of the season: 6 IP, 3 ER, 5 H, 1 BB, 12 K against Oakland
  • Opponents batting .260 against him with a concerning 1.69 WHIP

Pittsburgh Pirates: Paul Skenes (4-5, 2.15 ERA)

  • Dominating in his second MLB season with elite 2.15 ERA across 75.1 innings
  • Outstanding control with 77 strikeouts against just 18 walks (0.92 WHIP)
  • Coming off 6.2 scoreless innings against Arizona with 4 hits allowed
  • Opponents hitting a meager .187 against the young phenom
  • Looking for his sixth consecutive quality start

Advantage: Significant edge to Pittsburgh. Skenes has established himself as one of the premier pitchers in baseball, while McCullers is still working through his return-to-form process after missing nearly three years due to injury.

Bullpen Breakdown

Houston’s bullpen has been a source of stability this season, ranking 12th in MLB with a 3.85 ERA. They’ve been effective at limiting damage with a .220 opponent batting average, though the 3.14 walks per game represents an area of concern. The Pirates’ relief corps has been less reliable, posting a 4.20 ERA with frequent late-inning collapses, particularly evident in their 3-15 record in one-run games. The contrast in high-leverage situations is stark – Houston’s relievers have converted 12 of 15 save opportunities, while Pittsburgh has struggled to lock down victories. If this game reaches the late innings with a narrow margin, the Astros have a clear advantage despite being the road team.

Key Betting Trends & Team Statistics That Matter

  • Pittsburgh is just 11-19 at PNC Park this season, one of the worst home records in MLB
  • Houston is 15-14 on the road and has won 6 of their last 8 games overall
  • The Pirates are 5-11 in Skenes’ starts despite his excellence (run support averaging just 2.8 runs)
  • The Astros are 15-10 against teams with losing records this season
  • Pittsburgh ranks 30th in slugging percentage (.340) and 29th in home runs (43)
  • The Pirates have lost 10 of their last 14 interleague games
  • The under is 7-3 in Skenes’ last 10 starts
  • Houston is 19-9 when scoring 4+ runs this season

Skenes’ Dominance: Can the Pirates’ Ace Overcome Lack of Run Support?

Paul Skenes has emerged as one of baseball’s most electrifying pitchers, posting a remarkable 2.15 ERA with 77 strikeouts in 75.1 innings this season. His combination of a triple-digit fastball and devastating slider has made him nearly unhittable at times, holding opponents to a .187 batting average. What makes his 4-5 record particularly frustrating is the lack of run support – the Pirates have scored two or fewer runs in 7 of his 12 starts. Against an Astros lineup that can be feast-or-famine, Skenes’ ability to miss bats (9.2 K/9) matches up perfectly with Houston’s tendency to strike out (7.61 K/game). With trade rumors swirling despite management’s insistence he’s untouchable, tonight represents another opportunity for Skenes to demonstrate his ace status against a playoff-caliber opponent.

PNC Park Factor: How the Venue Influences Today’s Game

PNC Park continues to play as a pitcher-friendly venue, particularly for limiting home runs with its expansive left field. This works to Skenes’ advantage as a pitcher who already suppresses power (.187 batting average against), while potentially neutralizing Houston’s offensive strength (1.0 HR/game). The park’s tendencies should benefit both pitchers, though McCullers’ 1.69 WHIP suggests he’ll have more traffic on the bases, creating opportunities for damage even without home runs. Weather conditions for tonight call for comfortable temperatures around 71°F with minimal wind, further supporting a lower-scoring environment. When factoring in Pittsburgh’s offensive limitations (MLB-worst .340 SLG), the park effects magnify what’s already a challenging environment for run production.

Expert Prediction & Best Bets for Astros-Pirates Showdown

Primary Play: Pittsburgh Pirates Moneyline (-145)

I’m backing the Pirates on the moneyline despite their overall struggles because Paul Skenes has been nothing short of elite. The price of -145 might seem steep for a team that’s 22-38, but this bet is about the pitching matchup more than the teams’ records. McCullers is still finding his form after a lengthy injury layoff, while Skenes has been dominant with five consecutive quality starts. The young phenom has allowed more than 2 earned runs just once in his last eight outings. Pittsburgh’s offense is problematic, but they should manufacture enough against a vulnerable McCullers to secure a victory behind their ace. I’d play this up to -160.

Strong Value Play: Under 7.5 Total Runs (-110)

With Skenes on the mound and Pittsburgh’s offensive limitations, the under is compelling at 7.5. The Pirates rank dead last in slugging percentage (.340) and 28th in runs per game (3.23), making it difficult to envision them contributing significantly to the run total. While McCullers has been inconsistent, his 12-strikeout performance against Oakland suggests his stuff is still elite when commanded properly. PNC Park’s pitcher-friendly dimensions further support a lower-scoring affair. The under is 7-3 in Skenes’ last 10 starts, and I expect that trend to continue tonight.

Worth Considering: Paul Skenes Over 7.5 Strikeouts (+105)

The plus-money on Skenes’ strikeout prop offers excellent value. Houston strikes out at a 7.61 K/game clip, slightly above league average, while Skenes has recorded 8+ strikeouts in 6 of his 12 starts this season, including 9+ in three of his last five outings. His swing-and-miss stuff plays perfectly against an Astros lineup that can be aggressive. At plus-money odds, there’s tremendous value in backing the young phenom to rack up the strikeouts tonight.

Player Props Worth Targeting in Today’s Matchup

Player Prop Odds Rating
Paul Skenes Over 7.5 Strikeouts +105 ★★★★☆
Lance McCullers Under 5.5 Strikeouts -115 ★★★☆☆
Alex Bregman Under 0.5 Hits +195 ★★★☆☆
Oneil Cruz To Record a Hit -180 ★★★★☆
Yordan Alvarez Over 1.5 Total Bases +135 ★★☆☆☆

Final Thoughts: Pitching Premium Makes Pirates the Play

Despite Pittsburgh’s overall struggles this season, tonight’s matchup represents a significant pitching advantage that can’t be ignored. Paul Skenes has emerged as a genuine ace, and his dominance should be enough to overcome the Pirates’ offensive limitations. While the Astros have been playing better baseball recently, McCullers remains a work in progress as he continues his comeback journey. The combination of Skenes’ excellence, PNC Park’s pitcher-friendly dimensions, and Pittsburgh’s desperation to capitalize on their ace’s starts makes the Pirates moneyline the strongest play tonight. Don’t overthink this one – back the superior pitcher at home, even if his team’s overall record doesn’t inspire confidence.

Score Prediction: Pirates 4, Astros 2

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