Los Angeles Angels vs. San Diego Padres: MLB Betting Predictions
Date: Monday, May 12th, 2025 | 9:40 PM ET
Location: PETCO Park, San Diego, CA
TV Coverage: SDPA
Money Line: Angels +185 | Padres -218
Total Line: 7.5
Betting Preview
Here’s our comprehensive betting preview for the interleague matchup between the Los Angeles Angels and the San Diego Padres on Monday, May 12th at PETCO Park. We provide you with detailed analysis, current odds, and expert predictions to help with your handicapping decision based on the projected lineups and confirmed starting pitchers.
Betting Odds
| ML | RL | Total | |
|---|---|---|---|
| LAA | +185 | +1.5 | O 7.5 (+101) |
| SD | -218 | -1.5 | U 7.5 (-120) |
At 9:40 PM ET, the Angels and Padres square off in an interleague matchup at PETCO Park in San Diego. The Angels enter as significant underdogs at +185, while the Padres are heavily favored at -218. The over/under line is set at 7.5 runs.
Los Angeles (16-23) sits 5th in the AL West, while San Diego (25-14) is 2nd in the NL West. This matchup pits Yusei Kikuchi (LAA) against Michael King (SD) on the mound.
Team Standings & Current Form
Los Angeles Angels (16-23)
- Division Standing: 5th in AL West, 6 games behind Mariners
- Divisional Record: 1-7 (struggling against AL West teams)
- Home/Road Split: 9-10 home, 7-13 road
- Current Trend: 9-game road losing streak
- As Favorite/Underdog: 0-0 as favorite, 16-23 as underdog
- Series Record: 6-7
San Diego Padres (25-14)
- Division Standing: 2nd in NL West, 1 game behind Dodgers
- Divisional Record: 7-1 (excellent against NL West)
- Home/Road Split: 14-4 home, 11-10 road
- Current Trend: Won 2 straight home games
- As Favorite/Underdog: 0-0 as favorite, 25-14 as underdog
- Series Record: 8-5
Recent Game Recaps
Los Angeles Angels
The Angels dropped their series finale against the Orioles with a 7-3 loss at home. Los Angeles scored first but couldn’t maintain their early lead as Baltimore scored four runs in the sixth inning to pull away. The Angels entered as +124 underdogs.
Tyler Anderson struggled on the mound, allowing four earned runs on four hits while issuing two walks. Matthew Lugo provided the lone bright spot, homering in the first inning in his only at-bat.
San Diego Padres
San Diego suffered a disappointing 9-3 loss to close out their series against the Colorado Rockies. The Rockies jumped ahead with three first-inning runs, and the Padres managed only one run in response.
Nick Pivetta had a rough outing, surrendering six earned runs on seven hits and two walks. Gavin Sheets provided one of the few offensive highlights, going 2-for-4 with a run scored.
Projected Lineups
Los Angeles Angels
| Player | Batting Order | Position |
|---|---|---|
| Zach Neto | 1 | SS |
| Nolan Schanuel | 2 | 1B |
| Jorge Soler | 3 | DH |
| Taylor Ward | 4 | LF |
| Logan O’Hoppe | 5 | C |
| Luis Rengifo | 6 | 3B |
| Jo Adell | 7 | RF |
| Kyren Paris | 8 | CF |
| Tim Anderson | 9 | 2B |
| Yusei Kikuchi | – | SP |
San Diego Padres
| Player | Batting Order | Position |
|---|---|---|
| Fernando Tatis Jr. | 1 | RF |
| Luis Arraez | 2 | 1B |
| Manny Machado | 3 | 3B |
| Jackson Merrill | 4 | CF |
| Xander Bogaerts | 5 | SS |
| Jake Cronenworth | 6 | 2B |
| Brandon Lockridge | 7 | LF |
| Elias Díaz | 8 | DH |
| Martín Maldonado | 9 | C |
| Michael King | – | SP |
Team Records
Los Angeles Angels: 16-23 SU / OU 21-17 / Runline 16-23
San Diego Padres: 25-14 SU / OU 17-21 / Runline 25-14
Pitching Matchup Analysis
Yusei Kikuchi (LAA)
- Season Record: 0-4
- ERA: 3.83
- WHIP: 1.47
- Quality Starts: 4
- Home/Road Split: 1.7 ERA at home, 6.9 ERA on road
- Recent Form: Allowed 1 ER in 6 IP in last start
- Notable: Tagged for 4 home runs in a single outing this season
Michael King (SD)
- Season Record: 4-1
- ERA: 2.22
- WHIP: 0.98
- Quality Starts: 2
- Innings Pitched: 44.2
- Complete Games: 1 (shutout)
- Home/Road Split: 2.34 ERA at home, 3.65 ERA on road
- Recent Form: No-decision vs Yankees (6 IP, 2 ER)
- Note: Won 2 straight starts before last outing
Offensive Comparison
Los Angeles Angels
- Runs Per Game: 3.7 (25th in MLB)
- Team Hitting: Near bottom in batting average, OBP, and walks
- Power: 5th most home runs in MLB, 6th in isolated power
Key Performers:
- Jo Adell: .267 BA with 2 HR in last 5 games (season: .182 BA)
- Nolan Schanuel: 6-for-14 in last 4 games, .258 BA with 2 HR
- Logan O’Hoppe: Tied for team lead with 9 HR
- Mike Trout: Tied for team lead with 9 HR
San Diego Padres
- Team Batting Average: .266 (1st in MLB)
- Strikeouts: Fewest in MLB
- BABIP: 4th best in MLB
- Home Runs Per Game: 4.6 at home (9th in MLB)
Key Performers:
- Manny Machado: Red hot with 14-for-27 (.519) in last 7 games, .324 BA overall
- Fernando Tatis Jr.: 7-for-30 in last 7 games, .320 BA overall with 9 HR (team lead)
Analysis and Prediction
This interleague matchup features a stark contrast between two teams heading in opposite directions. The Padres boast MLB’s best team batting average (.266) and have been particularly strong at home (14-4), while the Angels struggle offensively, ranking 25th in runs per game (3.7).
The pitching matchup strongly favors San Diego. Michael King has been excellent with a 2.22 ERA and 0.98 WHIP, while Yusei Kikuchi’s dramatic home/road split (1.7 ERA at home vs. 6.9 ERA on the road) doesn’t bode well for his performance at PETCO Park.
The Padres’ offensive firepower is evident, especially with Manny Machado sizzling (14-for-27 in his last seven games) and Fernando Tatis Jr. providing consistent production. Meanwhile, the Angels have been in free fall on the road, dropping nine straight away games.
San Diego’s home success (14-4 record) contrasts sharply with Los Angeles’ road struggles (7-13 record). The Angels’ only strength appears to be their power (5th in home runs), but even that hasn’t translated to consistent run production.
Betting Pick: OVER 7.5 runs (+101)
While the Padres are heavy favorites at -218 (offering little value), the total presents an attractive opportunity. Despite the Angels’ offensive struggles, the Padres’ elite hitting should more than compensate. With Machado scorching hot and King facing a lineup desperate for runs, expect San Diego to put up substantial numbers. The Angels may struggle against King, but PETCO Park should see enough offensive production to push this game over 7.5 runs.
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